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modafinil will minimize the extent or impact of pacritinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.No unique dose adjustment encouraged when tofacitinib coadministered with strong CYP2C19 inhibitors; lower tofacitinib dose if coadministered with equally reasonable CYP3A4 and strong CYP2C19 inhibitors .In summary,